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Outcome measures included in trials to establish disease modification should include disease state assessment over 510 years while temporarily off all confounding symptomatic treatments (i.e., DBS and PD medications) with both appropriate clinical scales (i.e., UPDRS) as well as more innovative biomarkers 8,10,45
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The effect of genistein on IGF-1, PlGF, sFLT-1 and fetoplacental development
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