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May Reduce GI Side Effects vs
Structurally it differs from Melanotan II at a single terminal position: where Melanotan II ends in a primary carboxamide, PT-141 ends in a free carboxylic acid, and it is described in the analytical literature as the deamidation product of that parent molecule
Evidence of the impact of combination SGLT2i and GLP-1RA therapy on renal outcomes is limited
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Of clinical significance, the incretin effect has been shown to be impaired in patients with T2DM, as GLP-1 secretion is deficient in these patients
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