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FIGURE 4 4 Comparative overview of mainstream GLP-1RAs Over the past 2 decades, several GLP-1RAs have entered clinical practice, including short-acting exenatide, intermediate-acting liraglutide, and long-acting formulations such as dulaglutide and semaglutide, as well as the newer dual agonist tirzepatide
New developments should target some of the problems associated with existing treatments, such as muscle mass lost on GLP1s, she suggests
Table 2 summarizes NADs successfully applied in clinical experiments for treating human diseases
This results in a longer half-life of 20-30 hours instead of 20 min
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