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This rapid degradation occurs primarily through the enzyme dipeptidyl peptidase-4 (DPP-4) and neutral endopeptidase (NEP 24.11), along with renal clearance

Watch for signs of pancreatitis (severe abdominal or back pain, nausea, vomiting), unusual thirst or frequent urination (signs of blood glucose changes), nausea or loss of appetite beyond expected GLP-1 effects, and any infections or delayed wound healing (steroid-related concerns)

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findings were released during the conduct of this study 16