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In this regard it was recently observed that genomic features that affect the accessibility of a specific chromosome region to recombination, including GC content and CpG fraction, are altered in at least a proportion of oocytes with MI and MII errors, and particularly in those with recombinant events occurring in proximal regions, suggesting that factors characteristic of peri-centromeric DNA such as chromatin structure or epigenetic modifications may affect the accessibility of a specific chromosome region to recombination in at least a proportion of oocytes with meiotic errors (Oliver et al., 2014)

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One way to create friction is if you flip a coin, as you get to go to Starbucks and get the coffee that you love, and maybe it's not Starbucks, you pick it, okay, you know what

Cao X, Chen L, Lu K, et al