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6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation

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Theoretical synergy: three pathways working together Triple-pathway hypothesis: Why it might work: Non-overlapping receptor pathways Complementary not redundant Multiple appetite suppression mechanisms Enhanced metabolic effects Potential for greater weight loss than either alone Comparison to proven combinations: CagriSema (semaglutide + cagrilintide): 15-25% proven Tirzepatide alone: 15-22% proven Theoretical tirzepatide + cagrilintide: 20-30% unproven The critical problem: no clinical data What we DON'T know: Is the combination safe

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