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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
It is possible that GLP-1R agonists reduce cocaine seeking, in part, by increasing GABA release from presynaptic terminals in the VTA, effects consistent with the post-synaptic mechanism revealed in the current study
There was no change between groups in FVC or slope of FVC decline [164]
Large-scale human trials evaluating lifespan, disease prevention, or long-term aging outcomes do not currently exist
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