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Epac protein possesses carboxyl-terminal catalytic regions, which comprise CDC-25 homology GEF domain (CDC25-HD), Ras association (RA) domain, and Ras exchange motif (REM) domain, as well as the amino-terminal regulatory regions including cAMP-binding domain (cNBDs) and a disheveled, Egl-10, pleckstrin (DEP) domain (Bos, 2006)
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Oncotarget 8 (49), 8594985968 (2017)
Over time, carnosine buffers the pH decline that causes the onset of muscle fatigue and failure, while building endurance and improving recovery
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