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Lancet, 2021

Unverified anecdotal reports from online forums mention various effects, though these cannot be confirmed without proper clinical investigation and may not represent causal relationships: Unverified reports of hormonal changes : Some users mention changes in libido or sexual function, though no causality has been established Theoretical cardiovascular concerns : Based on its purported vascular effects, though no clinical evidence exists Injection site reactions : Pain, redness, or swelling when administered subcutaneously Gastrointestinal symptoms : Nausea or abdominal discomfort in some reports Unknown long-term effects : No data exists on prolonged use or cumulative toxicity A significant safety concern involves product quality and contamination

Patients should contact their GP or healthcare provider if they experience: Severe or persistent diarrhoea lasting more than 48 hours, particularly if accompanied by signs of dehydration (dizziness, reduced urination, dry mouth, confusion) Blood in stools or black, tarry stools, which may indicate gastrointestinal bleeding Severe abdominal pain , especially if constant or worsening, which could suggest pancreatitisa serious adverse effect that has been reported with GLP-1-based therapies

Sci Signal (2010) 3(112):re3