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Escalating to higher doses adds incremental benefit but also increases side effects
This binding subsequently recruits and activates initiator caspases-8/10 via adaptor proteins such as FADD/TRADD, leading to downstream activation of the effector caspases-3/7 and culminating in apoptosis [43]
While early immune responses may aid in the clearance of A and tau aggregates, prolonged activation of microglia and astrocytes leads to chronic inflammation and the release of pro-inflammatory cytokines such as IL-1 and TNF-, promoting neuronal damage in vulnerable brain regions like the neocortex and hippocampus [34,35,36]
Avoid repeated freeze-thaw of the same aliquot plan your aliquot sizes based on single-use volumes for your experimental design
