central and peripheral glp-1 systems independently suppress eating Glucagon, GLP-1 and Thermogenesis

The melanotan-1 dosage protocol begins with 0.25mg daily for 5 days to assess tolerance before escalating to 0.51.0mg maintenance dose for 1421 days total

Peptide drugs of this size (molecular weight approximately 711 Da) are typically cleared by a combination of renal filtration, endopeptidase activity in plasma and tissue, and hepatic proteolysis

Its estimated that almost 80% of people with binge eating disorder are also struggling with another mental health disorder- studies show that 65% of people suffering from binge eating disorder also present with anxiety, and can have up to six times more likelihood of being depressed

GLP-1 receptor agonists mimic naturally occurring incretin hormones that are released from the intestine in response to food intake