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The beneficial effects of GLP-1 RAs on HRQoL and other outcomes in HFpEF are likely due to pleiotropic impacts, related or not to weight reduction, such as decongestion (mainly due to the reduction of increased plasma volume associated with obesity and epicardial constrain), reverse cardiac remodelling (mainly due to the decrease in epicardial fat and regression of left atrial and LV myopathy, lowering intracardiac pressure) and anti-inflammatory actions, among others
This uptake prevents the Ca signal from spreading to the basal lateral region of the acinar cell, where the nucleus resides
It combines a Growth Hormone Releasing Hormone (GHRH) analog with a Growth Hormone Secretagogue (GHS), creating a much more potent and physiologically natural response than either compound could on its own
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