what's the difference of semaglutide and tirzepatide vs Tirzepatide vs. Semaglutide: What's Better

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (surpass-1): A double-blind, randomised, phase 3 trial

Typical Weekly Dosing Schedule: Weeks 14: 1mg once weekly Weeks 58: 2mg once weekly Weeks 912: 4mg once weekly Weeks 1316: 6mg once weekly Weeks 1720: 8mg once weekly ( if needed and well tolerated) Weeks 21+: 1012mg once weekly (max range, based on response and provider guidance) Key Points: Administer once weekly only (not split dosing) Increase dose every 4 weeks based on tolerance If side effects occur, hold or step back to the previous dose Patients often see appetite suppression early, with metabolic effects increasing at higher doses Significant Weight Loss Helps reduce body fat by decreasing appetite and increasing feelings of fullness, leading to sustained calorie reduction

Rapid weight loss with GLP-1 receptor agonists can also increase the risk of gallstone formation

Some studies suggest improvements in sperm quality, but research is still early