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Thus, lower levels of these metabolites in the starved urchin group would impair nucleotide synthesis, potentially leading to increased reliance on salvage pathways to maintain nucleotide pools

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Institute for Health Metrics and Evaluation (IHME)

Size, surface charge, and flexibility are important determinants for cellular internalization of NPs, with lipid-based NPs being more readily internalized than rigid silica or metal-based NPs ( The complexity of the physiological and pathophysiological barriers encountered during the systemic delivery of NPs to the brain complicates the development of successful NP-based therapeutics ( The review intends to give a broad and impartial presentation of the present status of nanoparticle-mediated drug delivery approaches for CNS disorders