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However, iron triggers the formation of free radicals via Fenton and Haber Weiss reactions during various metabolic activities [61,84] and presence of hesperidin before iron treatment might have blocked the generation of ironinduced free radicals resulting in the decline in iron-induced oxidative stress in the mice kidney

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Mechanically, the lactate produced by the CAFs can be used by cancer cells, thus enhancing aerobic glycolysis, which is called the reverse Warburg effect (272)

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