It can be given slowly into a muscle or through a vein
J Biol Chem 281:3059330602 Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI (2007) Mitochondrial GTP regulates glucose-stimulated insulin secretion
In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]
Accompanied by the downregulation of GPX4, lipid metabolic enzyme dysfunction further drives the disruption of lipid peroxidation and iron imbalance during the middle and late stages of renal fibrosis, which is consistent with previous report [13, 14, 36, 37]