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it addresses multiple cardiovascular risk factors, including dyslipidemia, hypertension, and obesity, making it a cornerstone in the comprehensive management of T2D patients with ASCVD
Because each sequence in the initial alignment has a length of 30 amino acids and each position can be mutated to one of 19 amino acids (20 if the position is gapped), this gives 570 single-step mutants in the first generation for each sequence in the training set, that is, 71,304 sequences, reducing to 69,639 sequences after removing duplicates
In clinical trial, it produced roughly a 6% reduction in body weight over 68 weeks
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