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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity
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But dig deeper into the clinical data, the receptor pharmacology, and the real-world side effect profiles, and these two treatments diverge in ways that matter enormously for researchers trying to decide between them
This route dependence is why GHK-Cu dosage cannot be expressed as a single universal figure
