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Diabetes 61:12431249 Pfeffer MA, Claggett B, Diaz R et al (2015) Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
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Periconception safety within a precautionary gray zone: an absence of a stable teratogenic pattern is not synonymous with proven safety. In the absence of robust human exposure-outcome evidence, periconception management must adhere to a defensive principle: continuous effective contraception combined with adherence to drug-specific discontinuation and washout protocols remains the mandatory safety boundary
These pharmacological effects contribute to improved glycaemic control and weight reduction but also underlie the medication's side effect profile
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