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The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
In ovalbumin-induced mouse asthma models, L-theanine treatment could reduce the transport of inflammatory cells to bronchoalveolar lavage fluid (BALF) and inhibit the infiltration of inflammatory cells via blocking the activation of NF-B pathway and its downstream production of ROS, monocyte chemoattractant protein-1 (MCP-1), IL-4, IL-5, IL-13, TNF-, and interferon (IFN)- in BALF (35)
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