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In the low-overdose patient (A), increasing zonation (20%80%) increased pericentral necrosis (by 13.2 times), with the number of necrosed cells increasing from 22 (1.29%) at 0% to 66 (3.87%) at 80% zonation, whereas in patient D (high overdose), increasing CYP450 zonation (20%80%) increased pericentral necrosis (by 3.33 times) from 36.25% (618 necrosed cells) to over 48% (831 necrosed cells), leaving only over 37% of healthy cells

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Zhang Q, Wang L, Wang S, Cheng H, Xu L, Pei G, Wang Y, Fu C, Jiang Y, He C, et al

This can result in cells going below the safe limit and causing damage