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If you accept the dual evidence that GLP-1/GCGR adds 3-6 percentage points of weight loss on top of GLP-1 alone, and you accept the tirzepatide evidence that GLP-1/GIPR adds 6-8 percentage points on top of GLP-1 alone, the arithmetic of a tri-agonist that captures both effects is intuitively additive
Published AOD-9604 research included a 12-week oral study and a 24-week oral study
This is not catastrophic
Early referral to hepatology, metabolic-bariatric surgery, or bariatric endoscopy specialists can help ensure patients receive timely care before progression to cirrhosis
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