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In particular, low micromolar to millimolar concentrations of Trolox are used in cell culture and in vivo applications ( Figure 5A , AX preincubation with PBS or Trolox did not significantly reduce AX-HSA adduct formation with respect to the adducts formed by the freshly prepared mixtures, whereas preincubation with TCEP showed a tendency towards decreasing adduct levels

Assess serum B12 level one month after each dose adjustment.If serum B12 levels are persistently low, consider alternative therapy (e.g., intramuscular or subcutaneous vitamin B12 therapy)

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