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Treatments focus on restoring commensal species and sealing the gut barrier to halt disease progression
Use is most often described after age-related collagen decline becomes visible, commonly from the mid-30s onward
Core Research Applications Metabolic health : Preclinical data indicate that NNMT inhibition may reduce fat cell size and support improved insulin sensitivity and glucose tolerance in diet-induced obesity models
5-on/2-off weekly pattern: Use DSIP Sunday through Thursday nights Take Friday and Saturday off Continue indefinitely with monthly full-week breaks This approach maintains consistent sleep support on work nights while allowing regular receptor recovery
