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The forest plots were checked for heterogeneity with the chi square test and I 2 statistics
= 1.8) compared to 4.0 mmol mol 1 (s.e
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These include: Nausea Vomiting Diarrhoea Constipation Decreased appetite (which, whilst therapeutically intended, can occasionally be excessive) Injection-site reactions (such as redness, bruising, or discomfort at the injection site) These effects were generally mild to moderate in severity and most frequently occurred during the dose-escalation phase of treatment, tending to diminish over time
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