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The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity
first reported a polymorphism in GPx1, namely, a substitution at codon 198 of either proline (Pro) or leucine (Leu), Pro198Leu (SNP: 1050450), in lung cancer [87]
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