Here, we find that semaglutide engages both G s and G q -dependent signalling pathways in Glp1r -expressing neurons in the area postrema (AP Glp1r ), the primary site of semaglutide action in the brain, and differentially regulates neuronal activation across distinct neuronal clusters
Strain selection, dose, duration, and individual baseline microbiota composition all influence outcomes dramatically
The R groups that can be protonated/deprotonated include Lys, Arg, and His, which have a + 1 charge when protonated, and Glu and Asp (carboxylic acids), Tyr and Ser (alcohols), and Cys (thiol), which have zero charges when protonated
Finally, each meal is an opportunity to nourish and fuel yourself, whether you are on a GLP-1 medication or not