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10 Molecular dynamics simulations including the GLP-1R

The result is pain

Originally developed for Type 2 diabetes management, these injectable peptide therapies including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have expanded into obesity treatment and are under investigation for cardiovascular disease, sleep apnea, Alzheimer's disease, and other indications

We also analyzed the expressions of testosterone synthesis-related enzymes, and the results showed that the protein expression and enzyme activity of 17-HSD were greatly reduced in both the HFC group and the KD group, suggesting that the conversion of androstenedione to testosterone was blocked (39)