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In obesity, discussions often focus on side effects, weight trajectories, and the importance of persistence

In the obese trial cohort, 1 mg moved 24-hour ambulatory heart rate by +0.7 bpm at week 24 the peak of the heart-rate curve, and below the placebo arms +0.8. In a healthy lean Phase 1 group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

In a recent trial studying the effectiveness of tirzepatide (Zepbound) for weight loss, participants lost an average of 20.9% of their body weight at 36 weeks

The anagen (growth) phase of a follicle runs 2 to 6 years