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Nat Rev Cancer 26 , 2745 (2026)

Possible Clinical Applications for ALS Patients Greater certainty in diagnosis of ALS, in combination with other clinical measures (e.g., ALSFRS-R score) Faster diagnosis of early-stage ALS, allowing for a decreased time period between symptom onset and initiation of treatment Monitoring of disease progression over time Un-biased efficacy assessment of approved therapeutics (Edaravone and Riluzole) and pre-clinical/clinical therapeutics that work to reduce extracellular glutamate Real-time results on the efficacy of pre-clinical and clinical therapeutics, leading to faster screenings of early stage candidates and reductions in failed late-stage candidates

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