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Long-Term Usability Approved for chronic weight management, Semaglutide supports sustainable lifestyle changes over time

To address this barrier of permeability, researchers have developed nuclear-localization signal (NLS), like simian virus-derived SV40 [284], and Trans-activating transcriptional activator (TAT) peptides, to functionalize nanocarriers and promote their active transport into the nucleus [285,286,287]