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Acknowledgements Work discussed in this Review was supported by a Wellcome Trust Senior Investigator Award (095531), the Knut and Alice Wallenberg Foundation, the Swedish Research Council, the Hartwell Foundation for Biomedical Research (201500731), the Juvenile Diabetes Research Foundation (CDA-2-2013-54) and the US NIH (DK110276)

17 In the late 19th century, the English physician Samuel Wilks and the English surgeon Thomas Henry Allchin first used the term chronic ulcerative colitis to describe the disease, which they systematically observed and described clinically