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This GIP-mediated enhancement of central GLP-1 delivery is a unique feature not available to mono-agonists, ensuring a more potent engagement of central pathways
Still, in the process, you do get more delay in gastric emptying, which is what leads to the drug interaction between tirzepatide and oral hormonal contraceptives. The FDA recommends that people using the drug also use backup birth control when starting injections and every time they increase their dosage
Szczuko M, Syrenicz A, Szymkowiak K, Przybylska A, Szczuko U, Pobocki J et al (2022) Doubtful Justification of the Gluten-Free Diet in the Course of Hashimotos Disease
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