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Vital organs like the heart, brain, and kidneys receive water first, while the skinbeing the body's largest organ but not immediately life-sustainingoften receives what's left over

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Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario

Am J Surg Pathol 34:14361441 Veraldi S, Cavicchini S, Benelli C et al (1991) Laugier-Hunziker syndrome: a clinical, histopathologic, and ultrastructural study of four cases and review of the literature