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Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons

In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig

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Many people describe this as the moment when the medication "kicks in" for real