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In any event, taken as a whole, our preclinical data point out that GLP1/E-based therapies would be superior than metformin also for an integral management of the metabolic and reproductive complications of milder cases of PCOS, with less severe metabolic alterations and preserved ovulatory function
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It is well-estabished that PPAR- agonists promote peroxisomal proliferation which can cause liver hypertrophy in rodents, but not humans 94
Medications like semaglutide only activate the GLP-1 receptor
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