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We additionally compared the anti-TMAO and anti-atherosclerotic efficacies of allicin with that of the TMA lyase inhibitor 3,3-dimethyl-1-butanol (DMB) 24 , which has been previously shown to reduce serum TMAO in carnitine-treated mice 17 , through studies in both wild-type and apolipoprotein E-deficient (ApoE / ) mice