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Chronic Dosing Protocol: AOD9604 administered intraperitoneally at 250 g/kg/day hGH administered at 1 mg/kg/day Treatment duration: 1428 days depending on cohort Daily administration via intraperitoneal injection Acute Testing Protocol: Single AOD9604 dose: 2 mg/kg 3-AR agonist BRL37344: 250 g/kg (for comparison) Indirect calorimetry measurements performed Measured Outcomes: Body weight, food intake, white adipose tissue (WAT) and brown adipose tissue (BAT) weights, plasma glycerol levels (indicating lipolysis), and 3-AR mRNA expression in adipose tissue

In a real world study, patients taking injectable semaglutide (Ozempic) had slightly greater average weight loss than those taking the oral form (Rybelsus), though the difference was not statistically significant

They recommend the incorporation of strength training 60-90 minutes per week as research has shown that this can be effective in preventing as much as 50-90% of lean muscle mass loss during caloric restriction

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