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Common gastrointestinal side effects (nausea, vomiting, diarrhoea) typically diminish within 48 weeks
PAIS metabolic disorder in the tryptophan- kynurenin pathway with impact on serotonin Tryptophan (trp) is a key precursor of serotonin (5-HT), which may be produced in the gut and in the brain
If that's the case which scientists haven't yet been able to establish it might help to explain why data suggests a link between the drugs and lower risks of other types of cancer occurring, spreading or turning deadly, too
Thats a real problem for patients, since dose escalation typically happens over the first 36 months of treatment
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