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This study published in the Annals of the Rheumatic Diseases indicates that GLP-1 receptor agonists might be disease-modifying for knee OA patients with comorbid T2DM, possibly mediated by weight loss, Lane said

For example, semaglutide and tirzepatide in prediabetes have shown remarkable efficacy in restoring normoglycemia and preventing T2D onset

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In real-world studies, GLP-1 RAs have consistently been associated with reduced cardiovascular risk in people with T2D [23,24,25,26,27,28], including reduced incidence of stroke (HRs between 0.65 and 0.74) and MI (HRs between 0.63 and 0.86)