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Additionally, repeated use and withdrawal can result in persistent overactivation of the HPA axis, causing elevated cortisol levels and disrupted negative feedback mechanisms 68,69,70,71

Our review intends to elucidate recent discoveries regarding the pathogenetic role of the most studied RCD, such as apoptosis, necroptosis, pyroptosis, ferroptosis and autophagy, in DKD, and provide a theoretical foundation for future investigations as well as targeted drug design

Epidemiological studies suggest that higher intake of CAF reduces the risk of Alzheimers disease (Eskelinen and Kivipelto 2010)

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