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However, the known contraindications that clinicians must observe include personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2 (MEN 2), both related to thyroid C-cell concerns identified in rodent studies
Members of the Rho GTPase family (e.g., Rac1, Rac2, Rac3, and cdc42) have been implicated in their activation by binding to an alternate site on the N-terminal PH domain followed by subsequent recruitment to the plasma membrane
van Hunsel, and A
& Marchesini, G
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