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FDA studies show no clinically relevant reduction in oral contraceptive efficacy with semaglutide, and no backup contraception is routinely recommended
Real-world reports have flagged some psychiatric symptoms, but the state-of-the-art review found no confirmed increase in suicidality, and monitoring continues (Kunutsor 2025)
Strange RC, Davis BA, Faulder CG, Cotton W, Bain AD, Hopkinson DA et al
No biosimilar versions of Skyrizi are available, but people can consider other lower-priced drugs for plaque psoriasis, psoriatic arthritis, or severe Crohns disease
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