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This modulation occurs by regulating the spinal dorsal horn microglial pathway through GLP-1R activation, leading to alterations in spinal excitatory synaptic transmission under neuropathic pain conditions 13,14,15,16,17,18
This dual action produces stronger appetite suppression and greater effects on fat metabolism, which is the leading explanation for why it outperformed Wegovy in head-to-head testing
This aligns with my clinical experience, where I frequently see a variable response to GLP-1 medications, said Mir Ali, MD, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA
In a follow-up proof-of-concept study by Aviles-Olmos et al., the longevity of motor and non-motor effects were assessed up to 24 months after the trial
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