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As a result, oxyThDP inhibits ThDP-dependent dehydrogenases, whose function is required for ACh synthesis, particularly pyruvate dehydrogenase complex generating ACh precursor acetyl-CoA (Figure 1)
Ledwozyw.MichalakA.StepienB.KadziolkaA.1986, Michalak B, Stepien A, Kadziolka A (1986) The relationship between plasma triglicerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis
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