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GLP1s delay gastric emptying which causes food to sit in the stomach for longer periods of time, which triggers nausea, says Micheal Currier, PA-C, The other mechanism resides in the central nervous system and is due to how the medication activates GLP-1 receptors in the area of the brain that controls nausea and vomiting, which then leads to an increase in nausea. How common is nausea on GLP-1 drugs