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Publicly available evidence from real-world examples in the US via the Veterans Administration (VA) includes their inclusion criteria language for resmetirom: Non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with METAVIR F2F3 fibrosis and non- alcoholic fatty liver disease (NAFLD) activity score (NAS) greater than or equal to 4 on liver biopsy in the past 36 months

Early side effects are predominantly gastrointestinal including nausea, vomiting, and changes in bowel habit and are managed through a gradual, pre-specified dose-escalation schedule

Another microarray assay compared early gene expression responses in A

It boosts metabolism by burning calories to produce heat (a process called non-shivering thermogenesis)