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Upon treating mucinous lung adenocarcinoma with the EGFR inhibitor gefitinib, the EGFR ligand amphiregulin promotes the binding of IGF-IR to importin-1 and triggers nuclear localization of IGF-IR, which in turn prevents the induction of apoptosis by gefitinib [117]
Animal Model:Naturally aged male C57BL/6 mice (20-24 months old) [1] Dosage:5 mg/kg Administration:Intraperitoneal injection, every other day for three administrations Result:Increased serum testosterone levels
4a, compared with OA group, the body weight of rats in OA + saline had no significant change at 0 day ( P = 0.9993), 7th day ( P = 0.8538), 14th day ( P = 0.5209), 21st day ( P = 0.3575) and 28th day ( P = 0.8092) after treatment with saline, which indicated that saline could not induce weight loss
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