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Additionally, most of the human evidence is derived from small randomized controlled trials and a number of observational studies with moderate risk of bias, which limits the certainty and generalizability of conclusions
This translates to approximately 1.6 to 4 mcg per kilogram of body weight, extrapolated from effective rat doses using standard interspecies scaling factors
This mechanism underlies its anesthetic, analgesic, and antidepressant properties
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