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It signals fibroblasts to produce collagen and elastin, accelerates wound and tissue remodeling, and shifts gene expression toward repair
The trade-off is pharmacokinetic: oral delivery subjects the peptide to stomach acid (pH roughly 1.5-2.0 fasting) and proteolytic enzymes including pepsin and pancreatic proteases before any absorption can occur
Reconstitution is required
The upregulation of NRF2 and SOD1, along with the activation of ROS scavenging pathways, can lead to resistance to chemotherapy or targeted therapy in various tumors
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